Wednesday, May 28, 2014

World MS Day 2014: What is Your Wish?

One day.  Today.  What is your wish?

World MS Day (WMSD) was established by the Multiple Sclerosis International Federation (MSIF) and its more than 67 member MS societies worldwide to create the only global awareness raising campaign for MS. Every year, the MS movement comes together to provide the public with information about MS and to raise awareness on how it affects the lives of more than two million people around the world.

This year MSIF asked people to imagine a world without barriers and to submit their One day wish to be shared on the Wish Wall launched today.  The Wall is a place to explore everyone's wishes and find out about access issues around the world.  This year's theme is quality of access which is about more than just getting into buildings or bathrooms.

What is a One day wish?

We all have hopes and dreams for the future, whoever we are and wherever we live. It may be to take a salsa class, write a novel, get your dream job, or even fall in love. A One day wish is your chance to share that wish with the world – a step towards overcoming whatever barriers might be in the way.

In related news, my friend George Pepper co-founder of shift.ms, a social network for MSers around the world to connect, gain information, and become empowered, has launched a new video in their series, this one addressing the question of whether to reveal your recent MS diagnosis at work.

Enjoy Circle of Truth.


Tuesday, May 27, 2014

May 2014 Round-Up of MS News and Research

On May 23, 2014, Biogen Idec received good news as EMA-CHMP released a positive opinion for the marketing authorization of Plegridy, a pegylated interferon administered by subcutaneous injection once every two weeks at a dose of 125 mcg for adults with RRMS. Plegridy offers a less frequent dosing schedule among the interferon class of treatments for MS. The most common side effects include injection site erythema, influenza-like illness, pyrexia (fever), headache, myalgia (muscle pain), chills, injection site pain, asthenia (weakness), injection site pruritus (itching), and arthralgia (joint pain). Plegridy is being developed by Biogen Idec who also markets Tecfidera, Avonex, Tysabri, Fampyra, and Rituxan.

In the phase III ADVANCE study involving more than 1500 people with RRMS, Plegridy demonstrated a reduction in relapses, disability progression and the number of MS lesions when compared to placebo. Data from the first year of the study demonstrated that Plegridy significantly reduced annualized relapse rate (ARR) at one year by 36%, reduced the risk of 12-week confirmed disability progression by 38%, and significantly reduced the number of new or newly enlarging T2-hyperintense lesions when compared to placebo. The ADVANCE two-year data was consistent with the positive efficacy and safety results observed in year one.

In other research news:
A new study shows that diets that are lower in magnesium and folate are correlated with higher fatigue scores in multiple sclerosis patients.

Researchers studying stem cell rejection following transplantation discovered that mice infected with the neurotropic JHM strain of mouse hepatitis virus (JMHV) who were injected with human neural precursor cells (hNPCs) derived from human embryonic stem cells (hESCs) experienced improved motor skills and a reduction in neuroinflammation and demyelination about two weeks after the injections. Mice who had been paralyzed regained the ability to walk.  Further studies are warranted.

Read this post in its entirety:

Hot Topics and MS Research News for May 2014

Monday, May 26, 2014

Does Gluten Affect RA?

People who have a wheat allergy may be sensitive to foods containing gluten.  However, it is important to note that it is the wheat contained in foods which causes an allergic reaction, not specifically gluten.  Wheat allergies are acute--within minutes or hours of consumption--and can be very severe.  Symptoms can include swelling, itching, or irritation of the mouth or throat; hives, itchy rash or swelling of the skin; nasal congestion; headache; itchy, watery eyes; difficulty breathing; cramps, nausea or vomiting; diarrhea; or anaphylaxis.
Approximately 3 million people in the United States have celiac disease, an autoimmune disorder of the digestive tract by which eating foods containing gluten results in damage to the finger-like villi of the small intestine and interferes with absorption of nutrients from food.  Celiac disease is difficult to diagnose because the symptoms often mimic other diseases.  More than 300 symptoms may be associated with celiac disease, including bloating or gas, itchy skin rash, headaches, depression, mouth sores, fatigue and joint pain.

Is gluten connected to rheumatoid arthritis?

A dietary link to rheumatoid arthritis has been suspected for decades and the effects of different diets on arthritis symptoms have been reported.  A number of patients with RA may self-report adverse reactions to certain foods, such as cow’s milk or wheat, without showing objective reactivity to these foods upon testing, according to a 2008 study (Lidén, 2008).  Researchers found that perceived food intolerance is reported by RA patients in similar percentages to the general population.  According to a study conducted over half a century ago, researchers determined that rheumatoid arthritis is not related to a gluten-induced intestinal defect (Binder, 1966).

More recent research, however, shows that a gluten-free vegan diet can improve the signs and symptoms of RA compared to a well-balanced, non-vegan diet.  This benefit may be related to a reduction in the immunoreactivity to food antigens that were eliminated by the change to a gluten-free vegan diet (Hafström, 2001).  For RA patients who also experience non-celiac gluten sensitivity, avoiding gluten may improve some of the overlapping symptoms such as joint pain, brain fog, and fatigue.

In another study, a gluten-free vegan diet in patients with RA decreased total cholesterol levels, low-density lipoprotein (LDL), and LDL/HDL ratio.  It did not significantly change high-density lipoprotein (HDL) or triglyceride levels.  The gluten-free vegan diet also induced lower body mass index (BMI) and higher levels of atheroprotective antibodies against phosphorylcholine (anti-PCs) of the IgA and IgM subclasses.  Anti-PCs help to protect against heart disease with an inverse relationship between low levels of anti-PC IgM and increased development of atherosclerosis (Elkan, 2008).

Read this post in its entirety:

Gluten and Rheumatoid Arthritis

Monday, May 19, 2014

Human Stem Cells Help Mice Regain Mobility

Researchers at the University of California stumbled upon an unexpected outcome while studying the common problem of stem cell rejection following transplantation.  Scientists injected human neural precursor cells (hNPCs) derived from human embryonic stem cells (hESCs) into the spinal cords of mice infected with the neurotropic JHM strain of mouse hepatitis virus (JMHV) http://www.ncbi.nlm.nih.gov/pubmed/11935460 .  Persistent infection with this particular virus causes an MS-like condition in mice characterized by demyelination, neuroinflammation, and hind-limb paralysis. 

As expected, the stem cells injected into the JHMV-infected mice were completely rejected by the immune system within 8 days.  However, unexpectedly, the hNPC-transplanted mice experienced improved motor skills and a reduction in neuroinflammation and demyelination about two weeks after the injections.  Results of a follow-up study cofunded by the National MS Society and the California Institute for Regenerative Medicine are published in the journal Stem Cell Reports in the article, “Human Neural Precursor Cells Promote Neurologic Recovery in a Viral Model of Multiple Sclerosis.”

Read this post in its entirety:

Mice with MS-like Disease Unexpectedly Walk After Stem Cell Transplantation

Sunday, May 18, 2014

Modeling MS in Mice to Study Remyelination

To investigate potential causes and treatments for demyelinating diseases such as MS, researchers use various methods to cause a condition or symptoms similar to MS in laboratory animals.  Mice do not naturally develop MS, but mice are especially suited to studying MS-like disease because of their similarity to humans in anatomy, physiology, and genetics.  Researchers are able to create various genetic modifications in mice to mimic human disease.  Mice are small, inexpensive, and can reproduce quickly.

There are three major types of animal models used to study demyelinating disease: 1) genetic models, where genes important for CNS myelination, myelin maintenance or glial function have been altered; 2) immune-mediated models of induced pathogenesis towards myelin; and 3) toxin-mediated models using toxic substances that preferentially affect myelin (Pohl, 2011).
- See more at: http://www.healthcentral.com/multiple-sclerosis/c/19065/169331/sclerosis-disease#sthash.WodvrOeA.dpuf
To investigate potential causes and treatments for demyelinating diseases such as MS, researchers use various methods to cause a condition or symptoms similar to MS in laboratory animals.  Mice do not naturally develop MS, but mice are especially suited to studying MS-like disease because of their similarity to humans in anatomy, physiology, and genetics.  Researchers are able to create various genetic modifications in mice to mimic human disease.  Mice are small, inexpensive, and can reproduce quickly. 

There are three major types of animal models used to study demyelinating disease: 1) genetic models, where genes important for CNS myelination, myelin maintenance or glial function have been altered; 2) immune-mediated models of induced pathogenesis towards myelin; and 3) toxin-mediated models using toxic substances that preferentially affect myelin (Pohl, 2011).

Read this post in its entirety:

Multiple Sclerosis Research: Studying MS-like Disease in Mice

Thursday, May 15, 2014

Can Nutritional Deficiencies Cause MS Fatigue?


  • Daily dietary intakes of vitamin D, folate, calcium, and magnesium were significantly lower than DRI as well. In men, zinc was significantly lower but iron was higher than DRI. In women, iron intake was significantly below DRI levels. Researchers have previously demonstrated that low calcium and iron intake may be correlated with progression of MS (Ramsaransing 2009).  In addition, deficiencies in vitamin D and magnesium have been implicated as risk factors for MS (Pennington 1997; Yasui 1992).

  • Fatigue and nutrient deficiencies

    In the current study, only the nutrients, folate and magnesium, were associated with increased fatigue.  Researchers found that lower dietary intake of magnesium and folate in MS patients is significantly correlated with higher Modified Fatigue Impact Scale (MFIS) scores, specifically the physical subscale.  Fatigue scores were not significantly associated with vitamin D and calcium intake.
  • - See more at: http://www.healthcentral.com/multiple-sclerosis/c/19065/169283/folate-correlates#sthash.kgaQt9nV.dpuf
    A recent study in Iran investigated the relationship between nutritional status (dietary intake of nutrients) and its relationship with fatigue in MS patients.  Researchers have found that diets which are lower in magnesium and folate are correlated with higher fatigue scores in MS patients (Bitarafan 2014).

    Daily dietary intakes of vitamin D, folate, calcium, and magnesium were significantly lower than DRI as well. In men, zinc was significantly lower but iron was higher than DRI. In women, iron intake was significantly below DRI levels. Researchers have previously demonstrated that low calcium and iron intake may be correlated with progression of MS (Ramsaransing 2009).  In addition, deficiencies in vitamin D and magnesium have been implicated as risk factors for MS (Pennington 1997; Yasui 1992).

    Fatigue and nutrient deficiencies

    In the current study, only the nutrients, folate and magnesium, were associated with increased fatigue.  Researchers found that lower dietary intake of magnesium and folate in MS patients is significantly correlated with higher Modified Fatigue Impact Scale (MFIS) scores, specifically the physical subscale.  Fatigue scores were not significantly associated with vitamin D and calcium intake.

  • Daily dietary intakes of vitamin D, folate, calcium, and magnesium were significantly lower than DRI as well. In men, zinc was significantly lower but iron was higher than DRI. In women, iron intake was significantly below DRI levels. Researchers have previously demonstrated that low calcium and iron intake may be correlated with progression of MS (Ramsaransing 2009).  In addition, deficiencies in vitamin D and magnesium have been implicated as risk factors for MS (Pennington 1997; Yasui 1992).

  • Fatigue and nutrient deficiencies

    In the current study, only the nutrients, folate and magnesium, were associated with increased fatigue.  Researchers found that lower dietary intake of magnesium and folate in MS patients is significantly correlated with higher Modified Fatigue Impact Scale (MFIS) scores, specifically the physical subscale.  Fatigue scores were not significantly associated with vitamin D and calcium intake.
  • - See more at: http://www.healthcentral.com/multiple-sclerosis/c/19065/169283/folate-correlates#sthash.kgaQt9nV.dpuf

  • Daily dietary intakes of vitamin D, folate, calcium, and magnesium were significantly lower than DRI as well. In men, zinc was significantly lower but iron was higher than DRI. In women, iron intake was significantly below DRI levels. Researchers have previously demonstrated that low calcium and iron intake may be correlated with progression of MS (Ramsaransing 2009).  In addition, deficiencies in vitamin D and magnesium have been implicated as risk factors for MS (Pennington 1997; Yasui 1992).

  • Fatigue and nutrient deficiencies

    In the current study, only the nutrients, folate and magnesium, were associated with increased fatigue.  Researchers found that lower dietary intake of magnesium and folate in MS patients is significantly correlated with higher Modified Fatigue Impact Scale (MFIS) scores, specifically the physical subscale.  Fatigue scores were not significantly associated with vitamin D and calcium intake.
  • - See more at: http://www.healthcentral.com/multiple-sclerosis/c/19065/169283/folate-correlates#sthash.kgaQt9nV.dpuf

    Read this post in its entirety:

    Low Magnesium and Folate Intake Correlates with Multiple Sclerosis Fatigue, New Study Shows

    Thursday, May 8, 2014

    Sex and Rheumatoid Arthritis

    So today, let’s talk about relationships and sex.  One of the most important aspects of any relationship is open communication.  A relationship without open communication makes it difficult for individuals to connect mentally, physically, or emotionally.  Sexual activity provides more than a physical connection, it binds people mentally and emotionally as well.  It also increases blood flow and releases endorphins which serve as the body’s own pain relievers, both which are good for RA.

    Open communication requires a willingness to be honest.  Rheumatoid arthritis may cause changes to the body which make sex more challenging.  You may experience pain and stiffness which interfere with comfortable movement.  Fatigue and depression (which are common with RA) may get in the way of desire and libido.  Medications you take for RA may also impact libido and sexual response.  Or your body may seem fragile, making your partner fearful of causing you additional pain or physical damage.

    Communicate with your partner about your concerns and do not be afraid to ask for what you need to be more comfortable.  Since RA can affect mobility and range of motion, experiment with different positions to avoid placing stress on parts of your body that are hurting or weak.  Rolled-up towels or blankets, pillows, specially-designed furniture, or props can be used to support your body.  The Department of Orthopaedics and Sports Medicine at the University of Washington offers tips for communication and new positions to consider when you have arthritis.  However, please be aware that if you have RA in the spine, in the neck specifically, it can be very dangerous to put any pressure on the neck during sex. 

    Read this post in its entirety:

    How Can I Improve My Sex Life with RA?

    Monday, May 5, 2014

    RA and Rheumatoid Vasculitis

    Rheumatoid vasculitis is a rare but serious complication of rheumatoid arthritis which occurs in 1-5% of patients diagnosed with RA (Genta 2006).  In rheumatoid vasculitis, inflammation of small and medium-sized blood vessels in the body restricts blood flow and causes tissue damage.  Multiple organs may be affected including the skin, nerves, eyes, heart, lung, brain, gastrointestinal tract or kidneys.  It most commonly affects the skin, arteries of the fingers and toes, peripheral nervous system, and eyes causing scleritis (an inflammation of the white part of the eye).

    Who develops rheumatoid vasculitis?

    Live Bold, Live Now Living With Rheumatoid Arthritis

    Vasculitis in RA is associated with longstanding (more than 10 years), erosive, seropositive disease.  It is more common in men than women with RA and in patients who smoke.  People who develop rheumatoid vasculitis usually have elevated sedimentation rate, rheumatoid factor, C-reactive protein, and anti-tissue antibodies (eg. anti-cyclic citrullinated polypeptides (anti-CCPs), antinuclear antibodies).  Patients with rheumatoid vasculitis will also often have rheumatoid nodules.

    Clinical reports have estimated the prevalence of RA vasculitis at less than 1% to 5% (Bartels 2009), whereas autopsy studies have reported 15% to 31% (Genta 2006).  However, it appears that rheumatoid vasculitis has been on the decline since the introduction of biologic therapies to treat RA (Bartels 2010).
    - See more at: http://www.healthcentral.com/rheumatoid-arthritis/c/72218/168959/rheumatoid#sthash.Rw9T0VPl.dpuf
    What is rheumatoid vasculitis?

    Rheumatoid vasculitis is a rare but serious complication of rheumatoid arthritis which occurs in 1-5% of patients diagnosed with RA (Genta 2006).  In rheumatoid vasculitis, inflammation of small and medium-sized blood vessels in the body restricts blood flow and causes tissue damage.  Multiple organs may be affected including the skin, nerves, eyes, heart, lung, brain, gastrointestinal tract or kidneys.  It most commonly affects the skin, arteries of the fingers and toes, peripheral nervous system, and eyes causing scleritis (an inflammation of the white part of the eye).

    Who develops rheumatoid vasculitis?

    Vasculitis in RA is associated with longstanding (more than 10 years), erosive, seropositive disease.  It is more common in men than women with RA and in patients who smoke.  People who develop rheumatoid vasculitis usually have elevated sedimentation rate, rheumatoid factor, C-reactive protein, and anti-tissue antibodies (eg. anti-cyclic citrullinated polypeptides (anti-CCPs), antinuclear antibodies).  Patients with rheumatoid vasculitis will also often have rheumatoid nodules.

    Clinical reports have estimated the prevalence of RA vasculitis at less than 1% to 5% (Bartels 2009), whereas autopsy studies have reported 15% to 31% (Genta 2006).  However, it appears that rheumatoid vasculitis has been on the decline since the introduction of biologic therapies to treat RA (Bartels 2010).

    Read this post in its entirety:

    What is Rheumatoid Vasculitis?

    Thursday, May 1, 2014

    Carnival of MS Bloggers #155

    Welcome to the Carnival of MS Bloggers, a monthly compendium of thoughts and experiences shared by those living with multiple sclerosis.

    by Lori at A Girl from MS and A Boy with MS

    I'm sorry is a phrase that is either really easy to say or really hard to say. Sometimes it is used lightly, and sometimes it is used in some pretty intense situations. In marriage and really in life in general, the art of saying I'm sorry and what it means is actually really complex.

    The first words Josh said to me after his diagnosis were "I'm Sorry." I am pretty sure I looked at Josh like he was an idiot. Why was he apologizing? Who says they are sorry for being sick? Are you kidding me? Being diagnosed with MS is something that is totally out of a person's control. Thinking about it now, I'm sorry is a little bit ironic. The things I really need Josh to say I'm sorry for are things like...
    • Sorry for leaving the toilet seat up, and the fact that you fall in the toilet at least once a week as a result of this.
    • Sorry for never unpacking my bags after business trips.
    • Sorry for falling asleep with a glass of red wine in my hand and waking up startled resulting in me drenching you with red wine at 3 in the morning. (True Story... Don't you feel sorry for me?)
    • Sorry for being grouchy when I wake up.
    • Sorry for leaving my work stuff scattered on the table.
    • Sorry for leaving empty glasses on the nightstand.
    Even after reading this list, the things I want him to say he is sorry for are pretty pathetic. They are such minor things in life. AND truthfully, I might miss some of these things if he ever quit doing them. Although, he is free to stop doing these things just so I can test out what it is like. :)

    On the MS front...

    The eye washout has not completely gone away. Josh needs a steroid for his eyes to knock out the inflammation. Dr. Emily called in IV Infusion that can be done at home. Sounds dramatic, but it really isn't-just more of an inconvenience. Josh does an incredible amount of paperwork for his job. Really, I may never understand the amount of paperwork that he does. The IV is being done at home which works out really well for him so he doesn't have to stop work. Just another perk of having a home office. He has to do 3 consecutive days of the steroid. We are hoping to get them started today and finish on Saturday. I laughed and told him maybe he will have a cute little nurse come out to set it up:). It amazes me how far technology and medicine has come. The fact that he can do this from home and it not have an impact on his work is truly amazing.

    Back to the "I'm Sorry's"...

    Our wedding was FUN. Like, so fun I didn't want to leave. In fact, when we left the reception the first time, no one was outside to see us leave. We had to do a redo and tell the band to stop playing music so everyone would come outside to see us hop in the limo to start our happily ever after. Our friends and family celebrated (maybe celebrated a little too much:), but the main part of our wedding was our vows. When I took those vows, I signed up for MS. I signed on the dotted line when I signed our marriage certificate. Did I know it at the time? No. When you are young and in love, you feel invincible. All you can imagine are picket fences, babies, puppies, and rainbows. (At least as a girl I imagined this. I would be interested to see what Josh imagined:) Would I do it all again and sign up for MS? Yep. And guess what? I. AM. NOT. SORRY. And guess what else? I will NEVER be sorry.

    by Lyla at Dear Diary

    I have been a runner in my lifetime. Some days I still feel like one, but most of the time I am happy to have the memorable experience of sustained motion. In 1999 a friend talked me into doing a "fun run" with her. She had just had her third child and wanted to get back in shape. She had been very involved in track during her college days and was really quite good, and fast.

    I said yes, and over the next five years I ran in several events including four marathons and three triathlons. In 2004 I had a training accident which inadvertently led to an MRI revealing evidence of demyelinating disease. My next marathon had begun. It took another six years of head scratching before the diagnosis came. Oddly welcome. Nice to know the reason why, right?

    Some questions though, do not have answers that feel satisfactory. And then there is the whole thing about not knowing what the future holds. All there really is to plant my feet on is what is in front of me right now. I am more than ok with that. Distance running is kind of the same. Being in the moment, being with myself is a big part of what I would try to do during a long run.

    Now the distances involve navigating the space between my CNS and my body, the emotions that surface with the myriad neurological sensations and the time it takes me to employ good old-fashioned self care. Running shoes are optional.

    by Cheri at I Tri not to Forget...

    After transitioning to the autoimmune paleo and Wahls protocols, I definitely have had more good days than bad, as far as my MS fatigue. I have also learned to be more in tune with my energy levels, and therefore what I schedule for the week, making sure I rest if I need to, so I don't crash.

    Having said all of that, there are days when I feel really good and I get caught up in the moment and push it too far. For example, last weekend, I started off my Saturday with a 1 hour vinyasa flow yoga class from yogaglo.com, then went for a walk with my daughter as she rode her scooter around our neighborhood and I ended up spending a couple hours in the afternoon out in my yard cleaning up the garden. I felt great and then it hit me, like somebody turned my switch to "off". I had just fixed dinner and then realized I was exhausted, and needed to lay down that minute. I basically ate dinner and went to bed and that was it for me. A couple months ago, I would have been down for the count the next day too, but I wasn't this time. I took it easy the next day, but I was still able to function, so I feel like I am making progress.

    I believe that my body is slowly healing, and I am making peace with this new life, but sometimes this "MSness" can just sneak up on me...


    This concludes the 155th edition of the Carnival.  The next Carnival of MS Bloggers will be hosted here on June 5, 2014. Please remember to submit a post (via email) from your blog of which you are particularly proud, or which you simply want to share, by noon on Tuesday, June 3, 2014.

    Photo Credit: Dawn - Pink Chick via Compfight cc